Comprehensive overview of Studies: Mapping on Personalised Prevention

Throughout the project, several mapping studies have been conducted, covering a wide range of topics from biomarkers, research programmes and projects to data management and infrastructures. The mapping study is an important step for the PROPHET project as it provides an overview of the current research on personalised prevention and thus enable to have a full understanding of the research advancements in this field.

An overview of each one is provided here:

  • Biomarkers and digital technologies for risk prediction : the aim was to map and review the research activity of biomarkers that are available or under development in cancer, cardiovascular and neurodegenerative diseases that are or can be used for personalised prevention in the general population, in clinical or public health settings.
  • Clinical usefulness of biomarkers for personalized disease prevention: the objective was to establish the level of evidence for clinical utility for personalized prevention of biomarkers in three disease groups: cancer, CVD and neurodegenerative diseases.
  • Existing Research Programmes in the field of Personalized Prevention : the aim was toreport the results of an extensive mapping research of the funding programmes and projects in the field of personalised prevention (PP) in Europe and internationally.
  • Critical factors for the successful adoption of Personalized Prevention approaches by healthcare systems : the aim was to underscore the potential of PP to enhance population health and reduce chronic disease burdens on healthcare systems. To achieve this, prioritizing PP on research and policy agendas is crucial, ultimately benefiting citizens and patients alike. Addressing the identified bottlenecks is pivotal in
  • Data management and infrastructure requirements to bring research advances into Health Systems, outlining challenges and best practices: A summary of the data management needs, in alignment with the B1MG : the work conducted underscores the complexity of implementing personalized prevention, offering critical insights and recommendations.
  • Current practices of citizens’, patients’, health professionals and policy makers engagement in Personalized Prevention and their gaps/bottleneck: A summary of the evidence mapping and desk research results. This research underlines the importance of the active participation of public and patients in care, research, education, and governance for meaningful engagement.
  • List of process and outcome indicators for the evaluation of the clinical utility of personalized preventive approaches: it aims to identify the outcomes and process indicators for evaluating under what circumstances a technology used in science would be applicable in practice.

All these mapping studies were presented in a workshop organized by UCSC on 14 March 2024.

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